A Definitive New Reference for the Latest Advances in B-12 Chemistry and Biochemistry Over the past decade, the field of B-12 research has been revolutionized by such major breakthroughs as the unraveling of the entire biosynthetic pathway for this important vitamin. This comprehensive compendium surveys the wealth of information that has accumulated, covering in one volume virtually all aspects of the field-from physical and inorganic chemistry to enzymology, microbiology, medicine, and diagnostic and therapeutic applications. Edited by Dr. Ruma Banerjee, a highly respected and active member of the B-12 community, this work provides B-12 researchers with a dependable and up-to-date reference on the subject. Leading authorities from five continents explore such new areas as the structural biology of B-12-dependent enzymes, free-radical-mediated reaction mechanisms, biosynthesis, and much more. The role of B-12 in nutrition and disease, and B-12 transport, are also thoroughly examined. Complete with color illustrations and extensive references, Chemistry and Biochemistry of B-12 is a one-of-a-kind resource for biochemists, biophysicists, spectroscopists, microbiologists, molecular biologists, and anyone with an interest in "nature s most beautiful cofactor." Die erste Arbeit, die den Erkenntnisstand zum Vitamin B12 umfassend beschreibt! Angesprochen werden biologische, biochemische und chemische Problemkreise, beispielsweise zur Strukturchemie des Vitamins, zu Strukturbiologie und Reaktionsmechanismen der B12-abhängigen Enzyme und zur Rolle des Vitamins in der Ernährung und bei der Entstehung von Krankheiten. (09/99)